Physiological-concentration platelet fibrin plasma vs supraphysiological-concentration platelet rich plasma for neuro-ischemic diabetic foot ulcer and other diabetic wounds: A randomized controlled trial.
Yunfeng Li, Jiwei Zhang, Zhiwen Yang et al.
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In 30 seconds
This single-center, noninferiority randomized controlled trial compared physiological-concentration platelet fibrin plasma (PFP) with supraphysiological-concentration platelet-rich plasma (PRP) during debridement suture surgery in patients with prepared diabetic wounds. The 56 participants included patients with diabetic foot ulcers, all neuro-ischemic, and wounds at other sites. At 4 weeks, healing was 78.6% with PFP and 71.4% with PRP; the trial confirmed noninferiority of PFP. Healing rates at other reported time points and mean healing time did not differ significantly.
Key findings
- Four-week healing was 78.6% with PFP versus 71.4% with PRP; noninferiority was confirmed (1-sided 95% CI lower bound -12.4%, P = .038).
- Mean healing time was 30.1 days with PFP and 32.2 days with PRP; the difference was not significant.
- No significant differences were reported in healing rates at 2, 3, 6, or 8 weeks.
Why it matters
The findings suggest that a physiological-concentration platelet product may achieve healing outcomes comparable to a higher-concentration product in this surgical setting. Because the study also describes PFP as requiring simpler preparation and less blood, it raises a practical consideration for wound care, while the single-center evidence and specific treatment context warrant caution in generalizing.
What to keep in mind
The trial was single-center and had a relatively small sample size.