Novel biomarkers for acute kidney injury in high-risk pediatric populations: a systematic review.
Ren FailJul 14, 2026 (epub)
Kyle Backston, Benjamin Buehrer, Defne Ezgü et al.
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In 30 seconds
This systematic review evaluated the diagnostic accuracy of novel biomarkers for early detection of acute kidney injury (AKI) in high-risk pediatric populations. It included 53 studies and identified neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, and cystatin-C as promising indicators. The review emphasizes the potential for these biomarkers to improve early diagnosis and intervention in pediatric AKI.
Key findings
- Neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, and cystatin-C showed significant promise as reliable indicators of kidney injury.
- The product of tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein-7 demonstrated potential as predictive markers of AKI.
- The review included 53 studies assessing novel biomarkers across various high-risk pediatric populations.
Why it matters
Acute kidney injury in children can lead to significant morbidity, and traditional methods often detect it too late. Identifying reliable biomarkers could facilitate earlier diagnosis and intervention, potentially improving patient outcomes.