Ibuprofen vs. acetaminophen for acute mild-to-moderate pain management: A systematic review and meta-analysis of safety with a focus on paediatric populations.
Br J Clin PharmacolJul 14, 2026 (epub)
Clinical ResearchPediatrics
Gian Luigi Marseglia, Paola Giovanna Marchisio, Gregorio Paolo Milani et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the safety of ibuprofen versus acetaminophen for managing acute mild-to-moderate pain in children and adolescents. Analyzing data from 15 studies involving 2847 patients, the findings indicated no significant difference in the risk of any adverse events between the two medications (RR 0.80, 95% CI 0.36-1.79).
Key findings
- Ibuprofen did not show a statistically significant difference in adverse events compared to acetaminophen (RR 0.80, 95% CI 0.36-1.79).
- No serious renal or hepatic adverse events were reported in the included studies.
- The review included 15 studies with a total of 2847 patients.
- Follow-up durations varied from single-dose assessments to 12 months.
Why it matters
Understanding the safety profiles of common analgesics in pediatric populations is crucial for clinicians to make informed decisions regarding pain management. This study provides evidence that may help guide medication choice in acute pain scenarios.