Effects of GLP-1 Receptor Agonists and Dual GIP/GLP-1 Receptor Agonists on Inflammatory and Metabolic Biomarkers in Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Diabetes Obes MetabJul 14, 2026 (epub)
Clinical ResearchEndocrinologyOpen access

Mehmet Kanbay, Ermeena Shah, Rama AlShiab et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and meta-analysis evaluated the effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists on inflammatory and metabolic biomarkers in adults with type 2 diabetes mellitus. The analysis included 41 randomized controlled trials. GLP-1 receptor agonists significantly reduced C-reactive protein (SMD -0.37) and malondialdehyde (SMD -0.98), while increasing adiponectin (SMD 0.30).

Key findings

  • GLP-1 receptor agonists significantly reduced CRP/hs-CRP (SMD -0.37).
  • Malondialdehyde levels decreased significantly with GLP-1 receptor agonists (SMD -0.98).
  • Adiponectin levels increased significantly (SMD 0.30).
  • Effects on IL-6 and TNF-α were not statistically significant.

Why it matters

Understanding the impact of GLP-1 receptor agonists on inflammatory and metabolic biomarkers can help clinicians optimize treatment strategies for patients with type 2 diabetes, potentially improving cardiovascular outcomes and overall metabolic health.

Source

PubMed · PMID 42449480Free full text on PubMed Central

Published in Diabetes Obes Metab. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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