532-nm KTP Laser Treatment of Epidermal Growth Factor Receptor Inhibitor-Associated Paronychia: A Case Report.
Emilee M Dreifus, Aditi Chokshi, Ariel E Eber
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Case in brief
A 67-year-old man with metastatic non-small cell lung cancer developed painful inflammation around multiple fingernails and both great toenails while receiving amivantamab. The lesions had pyogenic granuloma-like changes and persisted despite multiple topical therapies. A lesion on the left fourth digit was treated with two sessions of 532-nm potassium-titanyl-phosphate (KTP) laser. It showed marked improvement in erythema, pain, and friability, while untreated digits remained inflamed and symptomatic. No adverse events were observed.
What made this case unusual
The report describes successful KTP laser treatment of amivantamab-associated paronychia, with untreated digits providing a within-patient comparison.
Diagnostic / clinical pearl
In this case, painful, pyogenic granuloma-like periungual inflammation during amivantamab therapy persisted despite topical treatment; recognizing it as EGFR inhibitor-associated paronychia may help frame management options.