Diagnostic Accuracy of Optical Endoscopic Evaluation and EUS for Differentiating T1a and T1b Barrett's Adenocarcinoma: A Systematic Review and Meta-Analysis.
Rinrada Worapongpaiboon, Suchapa Arayakarnkul, Kasenee Tiankanon et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the diagnostic accuracy of optical endoscopic evaluation (OEE) and endoscopic ultrasound (EUS) in differentiating T1a from T1b Barrett's adenocarcinoma in 2,292 patients. OEE had a sensitivity of 55.3% and specificity of 75.1%, while EUS showed sensitivity of 66.1% and specificity of 89.3%. Both modalities demonstrated modest accuracy.
Key findings
- OEE had a pooled sensitivity of 55.3% and specificity of 75.1%.
- EUS demonstrated a sensitivity of 66.1% and specificity of 89.3%.
- The accuracy of OEE was 63.1%, while EUS had an accuracy of 82.8%.
- Paris 0-IIb lesions were significantly less likely to harbor T1b disease (DOR 0.17).
Why it matters
Accurate differentiation between T1a and T1b Barrett's adenocarcinoma is crucial for treatment decisions, particularly regarding endoscopic resection versus surgical intervention. Understanding the diagnostic performance of OEE and EUS can guide clinicians in selecting appropriate evaluation methods.