Efficacy of natural products in the treatment of melasma: A systematic review.
Maria Thereza Morais, Talita Lorena Nascimento Gonçalves, Luise de Paula Soares et al.
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In 30 seconds
This systematic review assessed the efficacy and safety of natural products for treating melasma in randomized controlled trials, focusing on the Melasma Area and Severity Index (MASI). Ten trials were included, revealing that natural compounds like lycopene and Aloe vera reduced MASI/mMASI scores by 20-70%, often comparable to 4% hydroquinone.
Key findings
- Natural products reduced MASI/mMASI scores by 20-70%.
- Effects of natural compounds were often comparable to 4% hydroquinone.
- Adverse events were generally mild, including transient irritation and erythema.
- Heterogeneity in formulations and small sample sizes limited evidence strength.
Why it matters
Understanding the efficacy of natural products provides clinicians with alternative treatment options for melasma, particularly for patients seeking less conventional therapies. The findings may influence treatment decisions and patient preferences.
What to keep in mind
Heterogeneity in formulations, small sample sizes, and short follow-up durations limited the overall strength of evidence.