Three-Year Follow-up of the Randomized Trial Comparing Open Versus Laparoscopic Surgery for Primary Tumor Resection in Patients With Noncurable Stage IV Colon Cancer (JCOG1107).
Akio Shiomi, Tomonori Akagi, Riku Kajikawa et al.
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In 30 seconds
The JCOG1107 trial was a multicenter, open-label, randomized controlled phase III study comparing laparoscopic and open surgery for noncurable stage IV colon cancer. The study found that laparoscopic surgery is noninferior to open surgery regarding progression-free survival, with 3-year rates of 3.0% for laparoscopic and 5.3% for open surgery (HR 1.028).
Key findings
- Three-year progression-free survival rates were 5.3% for open surgery and 3.0% for laparoscopic surgery.
- The hazard ratio for progression-free survival was 1.028, indicating noninferiority of laparoscopic surgery.
- Three-year overall survival rates were 31.5% for open surgery and 28.5% for laparoscopic surgery.
- Grade 3 or higher late complications occurred in 1.1% of open and 2.0% of laparoscopic patients.
Why it matters
Understanding the long-term outcomes of surgical options for noncurable stage IV colon cancer is crucial for treatment planning. This study supports laparoscopic surgery as a viable alternative to open surgery, potentially influencing surgical decision-making.
What to keep in mind
Chemotherapy was administered without knowledge of microsatellite instability or RAS/BRAF mutation status.