Long-term remission of severe psoriasis following CD19-directed chimeric antigen receptor T-cell therapy for follicular lymphoma.
Wayne P Gulliver, Jonah W Perlmutter, Susanne R Gulliver et al.
✦ AI-curated · Sources linked
Case in brief
A 60-year-old woman with a 49-year history of severe plaque psoriasis received autologous CD19-directed CAR-T therapy for follicular lymphoma. Her psoriasis cleared completely within 4 weeks, and she remained in remission for 5 years without psoriasis-directed treatment.
What made this case unusual
The sustained, treatment-free psoriasis remission followed CAR-T therapy given for lymphoma, rather than a psoriasis-directed intervention.
Diagnostic / clinical pearl
When psoriasis changes markedly after treatment for another condition, document the timing and durability of the response; this case links CD19-directed CAR-T therapy with prolonged clearance.
Why it matters
The observation raises the possibility that B-cell depletion may influence psoriasis beyond T-cell pathways, but a single case cannot establish mechanism or treatment efficacy.