From the archives of MD Anderson Cancer Center: Crystal-storing histiocytosis associated with B-cell lymphoma.

Ann Diagn PatholJul 12, 2026 (epub)
Case ReportOncology (Medical)

Omar Al-Rusan, Qi Shen, L Jeffrey Medeiros

✦ AI-curated · Sources linked

Case in brief

A 61-year-old man with a history of resected colon adenocarcinoma presented with a 5.5 cm right ureteral mass, hydronephrosis, lymphadenopathy, and splenomegaly. Biopsy revealed sheets of histiocytes filled with eosinophilic crystals, alongside small lymphocytes and plasma cells. Immunohistochemical analysis confirmed the presence of B-cell lymphoma associated with crystal-storing histiocytosis. The case was managed with further evaluation and diagnosis.

Diagnostic / clinical pearl

Clinicians should consider crystal-storing histiocytosis in patients with B-cell lymphoma presenting with unusual histological findings, particularly eosinophilic crystals within histiocytes.

Source

PubMed · PMID 42462588

Published in Ann Diagn Pathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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