Thermal ablation versus liver resection for small colorectal liver metastases (≤ 3 cm): a systematic review and meta-analysis of randomized and propensity score-matched studies.
Lei Su, Chengtao Yu, Chi Zhang et al.
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In 30 seconds
This systematic review and meta-analysis evaluated thermal ablation versus liver resection for small colorectal liver metastases (CRLM ≤ 3 cm) using data from seven studies. The analysis found no significant differences in overall survival (OS) or disease-free/progression-free survival (DFS/PFS) between the two treatments. However, thermal ablation was associated with lower overall and major complication rates (RR 0.38 and RR 0.35, respectively).
Key findings
- No significant difference in overall survival (HR 0.92, 95% CI 0.79-1.07) between thermal ablation and liver resection.
- No significant difference in disease-free/progression-free survival (HR 1.01, 95% CI 0.90-1.14).
- Thermal ablation associated with lower overall complication rates (RR 0.38, 95% CI 0.28-0.52).
- Thermal ablation associated with lower major complication rates (RR 0.35, 95% CI 0.22-0.55).
Why it matters
Understanding the comparative effectiveness and safety of thermal ablation versus liver resection for small CRLM is crucial for optimizing treatment strategies. This study provides evidence that may guide clinicians in selecting appropriate interventions based on individual patient profiles and complication risks.