Impact of oxytocin discontinuation on fetal heart rate and uterine contractility: A pre-specified ancillary analysis embedded within a randomized trial.
Acta Obstet Gynecol ScandJul 17, 2026 (epub)
Lise Lafforgue, Aude Girault, Loïc Sentilhes et al.
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In 30 seconds
This ancillary analysis of the STOPOXY trial evaluated the effects of oxytocin discontinuation on fetal heart rate (FHR) and uterine contractility in 284 women during active labor. Results indicated that discontinuation led to an increase in mean FHR (135 vs. 137.5 bpm; p < 0.002) and a decrease in uterine contractions (4.0 vs. 3.5 contractions per 10 min; p < 0.001).
Key findings
- Mean FHR increased from 135 to 137.5 bpm following oxytocin discontinuation (p < 0.002).
- The proportion of tracings with decelerations decreased from 64.1% to 48.6% (p < 0.001).
- Uterine contractions decreased from 4.0 to 3.5 contractions per 10 min (p < 0.001).
- FHR variability improved, with normal variability increasing from 48.2% to 53.3% (p = 0.010).
Why it matters
The findings suggest that discontinuing oxytocin during active labor may enhance fetal heart rate patterns and reduce uterine activity, potentially lowering fetal stress and the risk of tachysystole. This could inform labor management strategies.