Sacral Neuromodulation in Pediatric Gastrointestinal Motility Disorders: An Exploratory Prospective Cohort Analysis of Clinical Outcomes Based on Different Approaches.
NeuromodulationJun 15, 2026 (epub)
Frederike Bieling, Annemarie Kirchgatter, Angelina Bauer et al.
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In 30 seconds
This prospective cohort study evaluated the efficacy and safety of sacral neuromodulation (SNM) and enteral neuromodulation (ENM) in children with refractory gastrointestinal motility disorders. Among 48 participants, treatment success was achieved in 80% of the ENM group and 83% of the SNM group, with no major complications reported.
Key findings
- Treatment success was observed in 80% of the ENM cohort and 83% of the SNM cohort.
- Severe comorbidities were more frequent in the SNM group (45%) compared to the ENM group (3%; p = 0.0018).
- No major complications occurred during the study period.
- Minor adverse events were comparable between groups (ENM 27%; SNM 17%).
Why it matters
Understanding the effectiveness and safety of neuromodulation techniques in pediatric patients with gastrointestinal motility disorders can guide clinicians in selecting appropriate treatment options for this challenging population.