Relationship between participant-reported outcomes, residual beta cell function and metabolic parameters in youth with newly diagnosed type 1 diabetes.
Peter N Taylor, Wai-Yee Cheung, Joe Lagorio Price et al.
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In 30 seconds
This randomized controlled trial examined the relationship between participant-reported outcomes (PROMs) and metabolic parameters in youth aged 10-18 with newly diagnosed type 1 diabetes. The study found that PROMs, specifically the PedsQL and HFS scores, showed little change over 48 months, with baseline scores predicting future scores (p<0.001). Modest associations were observed between HbA1c and PedsQL (β (std) =-0.11) and CGM time in range and PedsQL (β (std) =0.14).
Key findings
- PedsQL scores were higher in children/adolescents than in their parents (p<0.01).
- HFS scores were higher in parents than children, indicating greater fear (p<0.001).
- HbA1c showed a modest negative association with PedsQL (β (std) =-0.11; 95% CI -0.20, -0.03).
- Beta cell function was strongly associated with HbA1c (β (std) =-0.29; 95% CI -0.39, -0.20).
Why it matters
Understanding the relationship between PROMs and metabolic parameters in youth with type 1 diabetes is crucial for evaluating treatment efficacy and patient quality of life. This study highlights the need for better tools to assess outcomes in this population.