Comparison of long-term outcomes between liver transplantation and liver resection for intrahepatic cholangiocarcinoma: An updated systematic review and meta-analysis.
Jiro Kimura, Ayham Asassfeh, Toshihide Tomosugi et al.
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In 30 seconds
This systematic review and meta-analysis evaluated long-term outcomes of liver transplantation (LT) versus liver resection (LR) for intrahepatic cholangiocarcinoma (ICC) in 5478 patients. The study found that 5-year overall survival was significantly higher in the LT group (OR 0.59, 95% CI 0.37-0.93, p=0.02) compared to the LR group, indicating a potential advantage of LT in selected patients.
Key findings
- 5-year overall survival was higher in the LT group compared to the LR group (OR 0.59, p=0.02).
- 5-year recurrence-free survival was also higher in the LT group (OR 0.44, p=0.02).
- No significant difference in 1-year OS (p=0.52) and 3-year OS (p=0.88) between LT and LR groups.
Why it matters
Understanding the comparative effectiveness of LT versus LR for ICC is crucial for optimizing treatment strategies and improving patient outcomes. This analysis highlights the potential for LT to enhance long-term survival in selected patients.
What to keep in mind
The evidence is limited due to the retrospective nature of the included studies and the influence of individual studies on statistical significance.