Continuous theta-burst stimulation over the right DLPFC modulates central executive network connectivity in depression: exploratory analysis of a randomized clinical trial.
Yun Wang, Jing Jin, Pengfei Wang et al.
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In 30 seconds
This randomized controlled trial explored the effects of continuous theta-burst stimulation (cTBS) over the right dorsolateral prefrontal cortex (DLPFC) on functional connectivity in 70 patients with major depressive disorder (MDD). The study found that active cTBS resulted in increased degree centrality in the precuneus and enhanced connectivity with the right inferior parietal lobule and DLPFC, indicating modulation of the central executive network.
Key findings
- Active cTBS led to greater improvement in depression scores compared to sham stimulation.
- Increased degree centrality in the precuneus was observed in the active cTBS group.
- Enhanced functional connectivity was noted between the precuneus and right inferior parietal lobule/DLPFC after cTBS treatment.
Why it matters
Understanding the neural mechanisms underlying the effects of cTBS on functional connectivity may inform treatment strategies for major depressive disorder, potentially enhancing therapeutic outcomes through targeted brain stimulation.