Simplified vitrification-warming protocol in donor oocytes: artificial intelligence-based oocyte competence and clinical outcomes.
Reprod Biomed OnlineJun 17, 2026 (epub)
Clinical ResearchObstetrics & Gynecology
Lucía Murria, Laura Conversa, Julia Gil et al.
✦ AI-curated · Sources linked
In 30 seconds
This randomized controlled trial evaluated a simplified vitrification and warming protocol for donor oocytes compared to a conventional method. Involving 245 mature oocytes from 20 donor cycles, the study found that oocyte survival rates were similar (97.7% vs 97.4%), with no significant differences in fertilization, blastocyst rates, or pregnancy outcomes, indicating the simplified method is as effective as the conventional approach.
Key findings
- Oocyte survival rates were 97.7% for the simplified protocol versus 97.4% for the conventional protocol.
- Fertilization rates were 83.5% for the simplified protocol compared to 77.7% for the conventional protocol.
- Implantation rates were 80.0% for the simplified protocol versus 71.4% for the conventional protocol.
- Ongoing pregnancy rates were 60.0% for the simplified protocol compared to 57.1% for the conventional protocol.
Why it matters
The findings suggest that a simplified vitrification and warming protocol can maintain high oocyte survival and clinical outcomes, potentially streamlining procedures in reproductive medicine without compromising effectiveness.