Sex Mismatch Does Not Affect Outcomes or Graft Survival After Osteochondral Allograft Transplantation of the Knee: A Systematic Review.
ArthroscopyJul 19, 2026 (epub)
Clinical ResearchOrthopedic Surgery
Colton C Mowers, Garrett R Jackson, Matthew T McKinley et al.
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In 30 seconds
This systematic review evaluated the impact of donor-recipient sex mismatch on outcomes after osteochondral allograft transplantation (OCAT) of the knee, analyzing 973 patients across four studies. The review found no consistent differences in graft survival or patient-reported outcomes between sex-matched and mismatched groups, although one study noted a higher failure rate in the mismatched cohort (21.2% vs 6.9%, P = .02).
Key findings
- No significant differences in failure or reoperation rates between sex-matched and mismatched grafts were found in three studies.
- One study reported a higher failure rate in the sex-mismatched group at 21.2% compared to 6.9% in the matched group.
- Failure rates across studies ranged from 5.2% to 21.2%, with bipolar grafts being the most reliable predictor of failure.
Why it matters
Understanding the influence of donor-recipient sex mismatch on OCAT outcomes can guide clinical decision-making regarding graft selection and patient counseling, potentially reducing unnecessary matching practices.