Effects of combined training on glycemic control and lipid profiles in middle-aged and older adults: A three-level meta-analysis of randomized controlled trials.
MaturitasJul 16, 2026 (epub)
Tianle Wang, Yunqing Zhang, Liuwei Zhang et al.
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In 30 seconds
This meta-analysis of 21 randomized controlled trials involving 1853 participants aged 45 and older assessed the effects of combined training (aerobic plus resistance) on glycemic control and lipid profiles. The study found that combined training significantly improved HbA1c (Hedges' g = -0.44, p < 0.01), HOMA-IR (Hedges' g = -0.59, p = 0.01), and glucose (Hedges' g = -0.81, p = 0.03) compared to control conditions.
Key findings
- Combined training improved HbA1c by Hedges' g = -0.44 compared to control conditions.
- HOMA-IR improved with combined training, showing Hedges' g = -0.59.
- Glucose levels decreased significantly with combined training (Hedges' g = -0.81).
- No clear additional benefit of combined training over aerobic training was established.
Why it matters
Understanding the effects of combined training on glycemic control is crucial for managing metabolic health in middle-aged and older adults, particularly as this population is at increased risk for diabetes and cardiovascular diseases.