Risk factors for loss of skeletal muscle mass in patients with chronic kidney disease on a low-protein diet.
NutritionJun 26, 2026 (epub)
Clinical ResearchNephrology
Satoko Notomi, Hideyuki Kabasawa, Toshiko Murayama et al.
✦ AI-curated · Sources linked
In 30 seconds
This multicenter randomized controlled trial examined risk factors for loss of skeletal muscle mass in 84 patients with chronic kidney disease (CKD) on a low-protein diet (LPD). The study found that 59.5% of patients experienced a decrease in skeletal muscle index (SMI) over 24 weeks. Key risk factors included baseline serum albumin levels and changes in energy intake during the diet.
Key findings
- 59.5% of patients experienced a decrease in skeletal muscle index (SMI) during the observation period.
- Lower baseline serum albumin was significantly associated with decreased SMI (odds ratio 0.11).
- Changes in energy intake while on the LPD were linked to reduced SMI (odds ratio 3.39).
Why it matters
Understanding the risk factors for muscle mass loss in CKD patients on a low-protein diet is crucial for maintaining their overall health and preventing further complications. Optimizing nutritional status can help mitigate these risks.