Autophagy potential of polyphenols in breast carcinoma: A systematic review.
Pathol Res PractJul 9, 2026 (epub)
Clinical ResearchOncology (Medical)
Asal Golchin, Shirin Teymori Nobari, Masomeh Maleki et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review evaluated the effects of polyphenols on autophagy in breast cancer, analyzing 48 studies, including 40 in vitro and 8 in vivo. Key findings indicate that curcumin, resveratrol, and carnosol effectively modulate autophagy pathways, with curcumin enhancing autophagic flux and resveratrol inhibiting tumor growth. However, translating these results to clinical outcomes remains challenging.
Key findings
- Curcumin modulated the PI3K/AKT/mTOR pathway, enhancing autophagic flux and reducing cell viability.
- Resveratrol consistently suppressed cancer stem-like cells and inhibited tumor growth in xenografted models.
- Carnosol induced autophagy by degrading STAT3 and downregulating p62, inhibiting metastasis and tumor growth.
Why it matters
Understanding the role of polyphenols in autophagy could inform future therapeutic strategies in breast cancer treatment. However, the challenge lies in translating these in vitro findings into effective clinical applications.