Optimizing prostate biopsy decision making - (MUSIC-screen): A 1:1 randomized controlled trial comparing micro-ultrasound versus multiparametric magnetic resonance imaging for prostate cancer diagnosis.
Contemp Clin TrialsJul 20, 2026 (epub)
Clinical ResearchUrology
Melis Guer, Alp Tuna Beksac, Wayne Brisbane et al.
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In 30 seconds
The MUSIC-Screen trial is a phase 3 randomized controlled trial comparing micro-ultrasound (microUS) to multiparametric magnetic resonance imaging (mpMRI) for prostate cancer diagnosis in biopsy-naïve men. The study aims to determine if microUS is non-inferior to mpMRI in detecting Grade Group ≥2 (GG ≥2) prostate cancer. A total of 1284 men will be randomized to either imaging modality.
Key findings
- The primary outcome is the detection of GG ≥2 prostate cancer in each study arm.
- MicroUS is hypothesized to be non-inferior to mpMRI for screening and detection of GG ≥2.
- Secondary objectives include comparing GG ≥2 detection rates in targeted cores among patients with PRI-MUS or PI-RADS scores of 3-5.
Why it matters
This study addresses a critical gap in prostate cancer screening by evaluating an alternative imaging modality that may influence biopsy decision-making, potentially improving patient outcomes and resource utilization.