Oral and Pancreatobiliary Microbiota in Cancer: A Systematic Review of Compositional Alterations and Their Clinical Implications.
J Oral Pathol MedJul 20, 2026 (epub)
Esperouz Fariba, Villani Rosanna, Ciavarella Domenico et al.
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In 30 seconds
This systematic review examined microbial dysbiosis in patients with pancreatobiliary malignancies, analyzing 16 studies with 1426 participants. It found that patients, particularly those with pancreatic ductal adenocarcinoma (PDAC), exhibited a higher abundance of opportunistic microbes and a lower abundance of commensal bacteria. The study highlights potential microbial signatures for future biomarker development.
Key findings
- Patients with pancreatobiliary cancers had a significantly higher abundance of opportunistic microbes like Streptococcus and Fusobacterium.
- Commensal bacteria such as Neisseria and Corynebacterium were found in lower abundance in these patients.
- Microbial profiles showed overlap between the oral cavity and tumor/bile compartments in some studies.
- The review included 16 studies with a total of 1426 participants.
Why it matters
Understanding microbial alterations in pancreatobiliary cancers may provide insights into disease mechanisms and potential diagnostic biomarkers, which could enhance early detection and treatment strategies.