Acute generalized exanthematous pustulosis sine pustules.
Justin Raman, Riley Shin, Mary Fitzgibbon et al.
✦ AI-curated · Sources linked
Case in brief
The report describes AGEP presenting without clinically evident pustules, an atypical presentation that can complicate diagnosis when medication exposure is unclear or several drugs have been started close together. Histopathologic evaluation of a skin biopsy was important in establishing the diagnosis. The abstract notes that prompt recognition and withdrawal of the offending medication can be followed by rapid resolution of the skin findings and systemic manifestations; it does not provide further patient-specific details.
What made this case unusual
AGEP occurred without visible pustules, potentially resembling a morbilliform drug eruption or drug reaction with eosinophilia and systemic symptoms.
Diagnostic / clinical pearl
When suspected AGEP lacks visible pustules, biopsy and histopathologic assessment can help distinguish it from other drug eruptions, especially with complex medication histories.