Correlation of Local Nasal Biomarkers and Olfactory Dysfunction in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis.
David Kayekjian, Neeti Gandra, Shaun A Nguyen et al.
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In 30 seconds
This systematic review and meta-analysis evaluated local biomarkers associated with olfactory dysfunction (OD) in chronic rhinosinusitis (CRS) patients. Analyzing data from seven studies involving 351 participants, it found that in CRS with nasal polyps (CRSwNP), several Type 2 cytokines were inversely correlated with olfactory function scores (r = -0.223 to -0.333). In CRS without nasal polyps (CRSsNP), IL-8 showed a negative correlation (r = -0.182).
Key findings
- In CRSwNP, IL-5, IL-6, IL-10, IL-13, IgE, CCL2, and CCL3 were inversely correlated with olfactory function scores (r = -0.223 to -0.333).
- CXCL5 and VEGF-A were positively correlated with olfactory function in CRSwNP (r = 0.240-0.247).
- In CRSsNP, IL-8 was negatively correlated with olfactory function scores (r = -0.182).
- CXCL5 was positively correlated with olfactory function in CRSsNP (r = 0.274).
Why it matters
Understanding the correlation between local biomarkers and olfactory dysfunction in CRS can help clinicians identify potential therapeutic targets and improve management strategies for patients experiencing olfactory impairment.