Structural Neuroimaging Alterations in Primary Burning Mouth Syndrome: A Seed-Based d Mapping (SDM-PSI) Meta-Analysis.
Int Dent JJul 21, 2026 (epub)
Chenghui Lu, Mengyu Jiang, Yanni Wang et al.
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In 30 seconds
This meta-analysis examined structural neuroimaging alterations in 59 patients with primary burning mouth syndrome (pBMS) compared to 63 healthy controls. The study found significantly reduced grey matter volume in the left medial superior frontal gyrus in pBMS patients, suggesting a potential neuroimaging signature of the condition.
Key findings
- Reduced grey matter volume in the left medial superior frontal gyrus in pBMS patients compared to healthy controls.
- The analysis included data from 59 pBMS patients and 63 healthy controls.
- Exploratory functional connectivity analyses were performed in two of the four included cohorts.
Why it matters
Understanding the neurobiological mechanisms underlying primary burning mouth syndrome can aid in the development of targeted interventions and improve management strategies for affected patients, enhancing their quality of life.