Pharmacogenomics of antipsychotic-induced weight gain: A systematic review.
Martin Kronenbuerger, Kazunari Yoshida, Pei Yuan Li et al.
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In 30 seconds
This systematic review examined the pharmacogenomics of antipsychotic-induced weight gain (AIWG) by analyzing 53 studies. It identified consistently replicated genes such as DRD2, HTR2C, and MC4R, along with novel associations from genome-wide association studies. The findings highlight the complexity of genetic contributions to AIWG, with no single variant currently suitable for clinical application.
Key findings
- Approximately 30% of patients experience antipsychotic-induced weight gain.
- Consistently replicated genes associated with AIWG include DRD2, HTR2C, and MC4R.
- Novel associations were identified from genome-wide association studies, including MAP2K1 and ZDBF2.
- Evidence remains inconsistent due to limited replication and methodological variability.
Why it matters
Understanding the genetic factors contributing to AIWG can help clinicians identify at-risk patients and tailor treatment strategies. However, the current lack of reliable genetic markers limits immediate clinical application.
What to keep in mind
The review highlights inconsistencies in evidence due to limited replication, methodological variability, and sparse ancestry data.