Seed-derived mucilage polysaccharides as biomaterials for in vivo tissue regeneration: A systematic review.
Gözde Özsezer, Eylul Erdal, Berk Deniz Tosunoglu et al.
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In 30 seconds
This systematic review evaluated the in vivo efficacy of seed-derived mucilage polysaccharides for tissue regeneration, focusing on chronic wounds, bone defects, and cartilage injuries. The review included 43 studies and found that these biomaterials generally improved outcomes such as wound closure and collagen deposition. However, many studies had limitations in design and reporting.
Key findings
- Hydrogels were the most common biomaterial format, followed by films and scaffolds.
- Seed-derived mucilages improved wound closure, re-epithelialization, and collagen deposition.
- Most studies utilized small animals and had short follow-up periods.
- Risk of bias was predominantly unclear due to insufficient reporting of randomization and blinding.
Why it matters
Understanding the potential of seed-derived mucilage polysaccharides can inform clinicians about innovative biomaterials that may enhance tissue regeneration in challenging clinical scenarios, such as chronic wounds and bone defects.
What to keep in mind
Most studies used small animals with short follow-up periods, and many incorporated nanoparticles, complicating the attribution of efficacy to the mucilage matrix alone.