Systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials on the impact of indocyanine green fluorescence angiography for anastomotic leakage in colorectal surgery.
SurgeryJun 24, 2026 (epub)
Clinical ResearchGeneral Surgery
Francesco Brucchi, Luigi Boni, Sara Lauricella et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the impact of indocyanine green fluorescence angiography on anastomotic leakage in colorectal surgery, involving 4,636 patients across seven randomized controlled trials. The study found that the anastomotic leakage rate was significantly lower in the indocyanine green group at 7.9% compared to 11.6% in controls (risk ratio, 0.69; P < .001).
Key findings
- Anastomotic leakage rate was 7.9% in the indocyanine green group versus 11.6% in controls (risk ratio, 0.69; P < .001).
- Significant reduction in anastomotic leakage for low colorectal or coloanal anastomoses (risk ratio, 0.63; P = .002).
- Fluorescence angiography reduced grade A leaks (risk ratio, 0.54; P = .006) and grade B + C leaks (risk ratio, 0.67; P = .006).
- Postoperative complications were modestly reduced in the indocyanine green group (risk ratio, 0.90; P = .035).
Why it matters
The findings suggest that indocyanine green fluorescence angiography can significantly reduce anastomotic leakage rates in colorectal surgery, which is crucial for improving patient outcomes and minimizing complications.