Effects of permissive hypercapnia on intraoperative cerebral oxygenation and early postoperative cognitive function in older patients with fragile brain function during the non-acute phase undergoing laparoscopic colorectal surgery: A randomized controlled trial.
Zhichao Li, Youzhuang Zhu, Xiaobin Lyu et al.
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In 30 seconds
This randomized controlled trial investigated the effects of permissive hypercapnia (PHC) on cerebral oxygenation and cognitive function in 76 older patients with fragile brain function undergoing laparoscopic colorectal surgery. The study found that PHC significantly increased intraoperative regional cerebral oxygen saturation (rSO2) compared to conventional ventilation, with an adjusted mean difference of 10.64 on the left and 10.16 on the right (both P < 0.001).
Key findings
- PHC increased rSO2 by an adjusted mean difference of 10.64 on the left and 10.16 on the right compared to conventional ventilation.
- Intraoperative rSO2 was consistently higher in the PHC group throughout the surgery.
- Early postoperative cognitive outcomes and serum biomarkers showed no significant differences between the two groups.
- Emergence time was modestly longer in the PHC group.
Why it matters
Understanding the impact of ventilation strategies on cerebral oxygenation in older patients with fragile brain function is crucial, as it may influence perioperative management and outcomes in this vulnerable population.