Herb-drug interactions with clinical impact: A systematic review of global clinical evidence on medicinal plants widely used in Ecuador.
J EthnopharmacolJul 21, 2026 (epub)
Raynier Zambrano-Villacres, Willington Montenegro-Acosta, Dolores Rodriguez-Veintimilla et al.
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In 30 seconds
This systematic review analyzed clinical evidence on herb-drug interactions involving medicinal plants commonly used in Ecuador. Among 47 studies, 31.9% reported clinically relevant interactions, with reduced plasma drug levels being the most frequent consequence. The findings highlight the need for increased awareness among healthcare professionals regarding these interactions.
Key findings
- 31.9% of studies reported clinically relevant herb-drug interactions.
- 40% of interactions resulted in reduced plasma drug levels.
- 13.3% of interactions increased the risk of bleeding.
- Commonly implicated plants included Camellia sinensis L. and Hypericum perforatum L.
Why it matters
Understanding herb-drug interactions is crucial for clinicians to prevent adverse events and ensure safe, effective patient care, especially in populations using medicinal plants.