Non-vascularized bone grafting for segmental mandibular reconstruction after oral cancer resection: A systematic review and meta-analysis.
Amanjot Kaur, Aparna Ganesan, Sibgutulah Rashid et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis evaluated the effectiveness of non-vascularized bone grafts (NVBG) for segmental mandibular reconstruction post-oral cancer resection. Analyzing 11 studies with 202 NVBGs, the overall success rate was 80.4%. The meta-analysis of 4 studies comparing irradiated and non-irradiated patients showed a pooled odds ratio of 2.83 for graft failure, indicating no significant difference.
Key findings
- The overall success rate of NVBGs was 80.4% across 11 studies.
- The pooled odds ratio for graft failure between irradiated and non-irradiated patients was 2.83.
- No statistically significant difference in graft failure was found (P = 0.12).
- The evidence quality was very low, with a wide confidence interval.
Why it matters
Understanding the effectiveness of NVBGs in mandibular reconstruction is crucial for clinicians managing post-oncologic patients, particularly those with prior radiation therapy, as it informs surgical decision-making and patient expectations.
What to keep in mind
The evidence quality was very low, and the confidence interval was wide, indicating uncertainty in the findings.