Maternal body mass index and periconception growth and development: a systematic review.
Rianne J de Bruin, Linette van Duijn, Merve Rousian et al.
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In 30 seconds
This systematic review examined the impact of maternal body mass index (BMI) on periconception outcomes, analyzing 101 studies. It found that high maternal BMI is linked to poorer reproductive outcomes, including reduced oocyte quantity and maturity, increased miscarriage risk, and compromised embryo quality. Specifically, 31 of 70 studies reported an association between high BMI and increased miscarriage risk.
Key findings
- High maternal BMI was associated with reduced oocyte numbers in nine of 43 studies.
- Maternal BMI correlated with increased risk of miscarriage in 31 of 70 studies.
- Negative associations with embryo quality were reported in 16 of 42 studies.
Why it matters
Understanding the relationship between maternal BMI and periconception outcomes is crucial for clinicians, as it highlights the need for early intervention and management strategies to improve reproductive health and pregnancy outcomes in obese women.