How I treat thrombotic microangiopathy in the setting of triggers.
Anuja Java, Meera Sridharan, Spero Cataland
✦ AI-curated · Sources linked
Case in brief
A patient presented with thrombotic microangiopathy during pregnancy, which complicated the diagnosis due to the potential trigger. Despite the clinical trigger, the patient's kidney injury pattern and lack of response to supportive care raised concerns about underlying complement dysregulation. Urgent complement blockade was initiated, leading to improved renal function and resolution of symptoms.
Diagnostic / clinical pearl
Clinicians should consider complement-mediated thrombotic microangiopathy in patients with kidney injury, even when a clinical trigger is present, especially if there is no improvement with standard care.
Why it matters
Recognizing the potential for complement dysregulation in the context of common triggers can prevent irreversible kidney damage and guide timely intervention.