Effect of SGLT2 inhibitor drugs on triglyceride-glucose (TyG) index in adults: A systematic review and meta-analysis.
Prim Care DiabetesJul 22, 2026 (epub)
Clinical ResearchEndocrinology
Mohammad Baadkoube Hazaveh, Fatemeh Naseri Rad, Hani Ghadri et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effect of SGLT2 inhibitors on the triglyceride-glucose (TyG) index in adults, analyzing data from 12 studies with 1845 participants. The findings indicated a significant reduction in the TyG index with SGLT2 inhibitor therapy, with a mean difference of -0.28 (95% CI [-0.41; -0.14]).
Key findings
- SGLT2 inhibitor therapy led to a mean reduction in TyG index of -0.28.
- The analysis included 12 studies with a total of 1845 participants.
- Follow-up durations varied from 12 weeks to 5 years.
- High heterogeneity was noted across the included studies.
Why it matters
The TyG index serves as a practical surrogate for insulin resistance, and understanding the impact of SGLT2 inhibitors on this index can inform clinicians about their broader metabolic effects beyond glycemic control.