Clinical Trial: Multi-Strain Probiotic Improves Bile Acid Profile, Microbiome, and Metabolomic Parameters in Patients With History of Bile Acid Malabsorption-A Randomized, Controlled Trial.
Aliment Pharmacol TherJul 23, 2026 (epub)
John A Damianos, Ayah Matar, Paula Carlson et al.
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In 30 seconds
This randomized controlled trial evaluated the effects of a multi-strain probiotic on bile acid malabsorption (BAM) in 24 patients. The study found that probiotic supplementation significantly decreased the percentage of faecal primary bile acids, with a median change of -5.7% compared to a 9.8% increase in the placebo group (p = 0.012).
Key findings
- Probiotic group showed a median decrease in % faecal primary BAs of -5.7% compared to 9.8% increase in placebo (p = 0.012).
- Significant changes in the faecal microbiome were observed in the probiotic group post-intervention.
- No significant differences were found in symptoms, intestinal permeability, or SCFA levels.
Why it matters
Understanding the impact of probiotics on bile acid profiles and gut microbiota can inform treatment strategies for patients with bile acid malabsorption, potentially improving their quality of life.