Low-intensity exercise reduces negative affect via circulating endocannabinoid dynamics in healthy young adults.

Eur J Appl PhysiolJul 23, 2026 (epub)
Clinical ResearchPsychiatryOpen access

Tetsuya Yabe, Daisuke Ando, Katsuhiro Koyama

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In 30 seconds

This randomized crossover trial investigated the effects of low-intensity exercise on negative affect and circulating endocannabinoids in 30 healthy young adults. Results indicated that low-intensity exercise significantly reduced negative affect, although changes in plasma endocannabinoid levels (AEA and 2-AG) were inconsistent. Notably, a significant negative correlation was found between plasma AEA concentrations and negative affect in the low-intensity condition.

Key findings

  • Low-intensity exercise significantly reduced negative affect in participants.
  • Plasma endocannabinoid concentrations showed substantial inter-individual variability.
  • A significant negative correlation was observed between plasma AEA and negative affect.
  • Cumulative plasma AEA and 2-AG levels did not correlate with mood improvements.

Why it matters

Understanding the relationship between low-intensity exercise and mood enhancement can inform mental health management strategies. This study highlights the potential role of endocannabinoid dynamics in improving emotional well-being through exercise.

Source

Published in Eur J Appl Physiol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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