Efficacy of Proton Pump Inhibitor Therapy for Nocturnal GERD Symptoms and Associated Sleep Disturbances: A Systematic Review of Randomized Controlled Trials.
Thai Hau Koo, Fahmi Shibli, Amir Mari et al.
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In 30 seconds
This systematic review evaluated the efficacy of proton pump inhibitor (PPI) therapy for nocturnal gastroesophageal reflux disease (GERD) symptoms and associated sleep disturbances in adults. Analyzing five randomized controlled trials with 1495 patients, the review found that PPI therapy significantly improved nighttime heartburn relief and GERD-related sleep disturbances compared to placebo, with similar treatment-emergent adverse events reported in both groups.
Key findings
- PPI therapy improved nighttime heartburn relief compared to placebo in three trials.
- GERD-related sleep disturbances were significantly reduced with PPI therapy.
- Subjective sleep quality and daytime functioning generally improved with PPI treatment.
- Treatment-emergent adverse events were similar between PPI and placebo groups.
Why it matters
Understanding the efficacy of PPI therapy for nocturnal GERD symptoms is crucial for clinicians managing patients with sleep disturbances related to reflux. Effective treatment can enhance patient quality of life and overall well-being.