Deprescription of Psychotropics in Children and Adolescents: Systematic Review of Guidelines and Development of a Deprescribing Algorithm.
Paul-Benoît Fargier, Mark Horowitz, Rodolphe Charles et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review evaluated clinical practice guidelines for deprescribing psychotropics in children and adolescents. Among 1390 records, none met formal criteria for guidelines, but two papers provided moderate-quality recommendations. One suggested tapering antidepressants after remission, while the other advised reassessment of stimulants after one year of stability, highlighting a critical gap in pediatric deprescribing strategies.
Key findings
- None of the 1390 records strictly met the criteria for formal clinical practice guidelines.
- One systematic review recommended tapering antidepressants after remission with gradual dose reduction.
- A narrative review suggested reassessment and possible discontinuation of stimulants after one year of stability.
- Both papers provided limited practical detail on stepwise deprescribing procedures.
Why it matters
The lack of structured deprescribing guidelines for psychotropics in youth poses challenges for clinicians managing pediatric patients. Understanding when and how to safely reduce or discontinue these medications is essential for optimizing treatment and minimizing potential harm.