Asymptomatic spinal cord lesions in Multiple Sclerosis: A systematic review and meta-analysis of subclinical disease activity.
Mult Scler Relat DisordJul 24, 2026 (epub)
Mario Rotolo, Rocco Capuano, Sara Scannapieco et al.
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In 30 seconds
This systematic review and meta-analysis examined the occurrence of new asymptomatic spinal cord lesions (aSCLe) in clinically stable patients with Multiple Sclerosis (MS). Among 1637 patients, the pooled proportion developing at least one new aSCLe was 13.0% (95% CI 6.2-25.1). In relapsing-remitting MS, this proportion was higher at 19.1% (95% CI 13.2-26.7).
Key findings
- The pooled proportion of patients developing at least one new aSCLe was 13.0%.
- In relapsing-remitting MS, the proportion was 19.1%.
- Isolated spinal cord activity was reported but could not be pooled due to heterogeneous definitions.
Why it matters
Understanding the frequency of asymptomatic spinal cord lesions is crucial for clinicians, as these lesions may contribute to long-term disability and may be overlooked if only brain MRI is used for monitoring.