High-flow nasal cannula oxygenation in sedated endoscopy for high-risk obstructive sleep apnea patients: study protocol for a multicentre randomised controlled trial.
Mingxia Xu, Saiheng Xiang, Yongmin Pi et al.
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In 30 seconds
This multicenter randomized controlled trial aims to evaluate the efficacy of high-flow nasal cannula (HFNC) oxygenation in preventing hypoxemia during sedated gastroenteroscopy in 600 high-risk obstructive sleep apnea patients (STOP-Bang score ≥5). The study compares HFNC (30 L/min pre-oxygenation, 60 L/min post-induction) to conventional nasal cannula (6 L/min), with the primary outcome being the incidence of hypoxemia (SpO2 75%-90% <60s).
Key findings
- The primary outcome measures the proportion of patients experiencing hypoxemia (SpO2 75%-90% <60s).
- Secondary outcomes include severe hypoxemia (SpO2 <75% or 75% ≤ SpO2 <90% ≥60s).
- The study will also assess subclinical respiratory depression (90% ≤ SpO2 <95%).
- The trial aims to enhance procedural safety for high-risk OSA patients.
Why it matters
Hypoxemia is a significant risk during sedation in patients with obstructive sleep apnea. Understanding the effectiveness of HFNC could lead to improved safety protocols and management strategies during gastrointestinal endoscopy in this vulnerable population.