Positive End-Expiratory Pressure, Tidal Volume, and Fraction of Inspired Oxygen During General Anaesthesia in High-Risk Patients-A Randomised Clinical Feasibility Trial.
Maria B Pælestik, Benjamin H Risager, Signe Ø Mortensen et al.
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In 30 seconds
This multicenter randomized clinical trial evaluated different ventilatory settings during general anesthesia in 483 high-risk patients (ASA 3-5). While feasibility goals were not met, cardiac arrhythmias were more common in the PEEP-8 and PEEP-10 groups, with odds ratios of 9.32 and 6.71, respectively. Additionally, pneumonia and emergence delirium were more frequent with FiO2 of 80% compared to 30%.
Key findings
- Cardiac arrhythmias were more frequent in the PEEP-8 and PEEP-10 groups, with odds ratios of 9.32 and 6.71.
- Pneumonia occurred more frequently in patients with FiO2 of 80% compared to 30%, with an odds ratio of 4.04.
- Emergence delirium was more common in the FiO2 80% group, with an odds ratio of 5.56.
Why it matters
Understanding the impact of different ventilatory settings on postoperative outcomes is crucial for optimizing care in high-risk surgical patients. This study highlights potential complications associated with specific settings, informing anesthetic management.