Efficacy and safety of prehospital whole blood resuscitation in traumatic haemorrhagic shock a systematic review and meta-analysis.
Yasir Y Khan, Abdulelah A Alzahrani, Ruba S Alghamdi et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the efficacy and safety of prehospital whole blood (WB) resuscitation versus standard blood components (BC) in adults with traumatic haemorrhagic shock. Analyzing three RCTs involving 2048 patients, the study found no significant difference in 24-hour all-cause mortality between WB and BC (OR 1.12, 95% CI 0.81-1.55; p = 0.49).
Key findings
- No significant difference in 24-hour all-cause mortality: OR 1.12, 95% CI 0.81-1.55; p = 0.49.
- 28-30-day mortality also showed no significant difference: OR 1.15, 95% CI 0.90-1.47; p = 0.28.
- Massive transfusion within 24 hours did not differ significantly: OR 1.09, 95% CI 0.80-1.50.
Why it matters
Understanding the effectiveness of prehospital whole blood resuscitation is crucial for optimizing treatment protocols in traumatic haemorrhagic shock, potentially impacting patient outcomes in emergency settings.
What to keep in mind
The analysis included only three trials of limited size and quality, which may affect the robustness of the findings.