Outcomes of Congenital Neuroblastoma With Placental Metastases: A Systematic Review.

In 30 seconds

This systematic review examined outcomes of congenital neuroblastoma with placental metastases, analyzing 16 articles and identifying 19 cases. The majority (84.2%) of cases resulted in stillbirth or neonatal death, with only two patients surviving beyond one year. Most cases had adrenal primaries detected antenatally in 26% of instances.

Key findings

• 16 out of 19 cases resulted in stillbirth or death in the neonatal period.
• 89.5% of cases had an adrenal primary tumor.
• 26% of cases were detected on antenatal ultrasound.
• Only two patients survived beyond the first year of life.

Why it matters

Understanding the outcomes and risk factors associated with congenital neuroblastoma and placental metastases is crucial for early detection and management. Clinicians should consider histopathological analysis of the placenta in cases of unexplained fetal hydrops and placentomegaly.