Epigenetic aging biomarkers in dietary geroscience: feasibility, participant perceptions, and trial design considerations.
GeroscienceJul 29, 2026 (epub)
Lindsay M Reynolds, Timothy D Howard, Carl D Langefeld et al.
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In 30 seconds
This randomized controlled trial assessed the feasibility of using epigenetic aging biomarkers in dietary interventions among 34 adults aged 48-81 with metabolic syndrome. Participants consumed tree nuts and olive oil for 4 weeks, achieving over 95% adherence. Although no significant changes in biological aging were observed, the study highlights the potential for using these biomarkers in future dietary geroscience research.
Key findings
- Adherence to the dietary intervention exceeded 95%.
- All participants exhibited a faster pace of biological aging than average at baseline.
- Participants showed strong interest in learning their biological age.
- No significant changes in epigenetic aging were observed over the 4-week intervention.
Why it matters
Understanding the feasibility of incorporating biological aging measures into dietary interventions can enhance participant engagement and inform future research designs aimed at promoting healthy aging.