18 F-FDG PET/CT Findings in an Infant With Multisystem ALK-Positive Histiocytosis.
Nivedita Kundu, Khangebam B Chandra, Dikhra Khan et al.
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Case in brief
A 5-month-old girl presented with pancytopenia and hepatosplenomegaly. Whole-body 18F-FDG PET/CT showed intensely avid disseminated disease involving the brain, left parapharyngeal/skull-base region, lungs, liver, pancreas, kidneys, genital tract, soft tissues, muscle, spinal canal region, and skeleton. The findings were reported as multisystem ALK-positive histiocytosis. The abstract does not describe treatment or clinical outcome, so resolution cannot be summarized.
What made this case unusual
The PET/CT demonstrated extensive multiorgan disease, including involvement of the cervix/lower uterine body with vaginal extension and the vulva—an imaging pattern that broadens the described spectrum of this neoplasm.
Diagnostic / clinical pearl
In an infant with suspected multisystem ALK-positive histiocytosis, whole-body FDG PET/CT can reveal extensive disease across multiple organ systems, including genital-tract involvement.