Benign Hyperplastic Nodule in the Peripheral Zone of the Prostate Mimicking Prostate Cancer on 18 F-PSMA-1007 PET/CT.
Xiaojun Man, Changming Dong, Aisheng Dong et al.
✦ AI-curated · Sources linked
Case in brief
A patient presented with a large benign hyperplastic nodule located in the peripheral zone of the prostate, which is an atypical site for benign prostatic hyperplasia. Imaging studies, including MRI and 18 F-PSMA-1007 PET/CT, revealed a well-defined mass with heterogeneous signal intensity and increased uptake of 18 F-PSMA-1007, mimicking prostate cancer. The nodule was ultimately diagnosed as benign.
What made this case unusual
The benign hyperplastic nodule's location in the peripheral zone is rare, as benign prostatic hyperplasia typically occurs in the para-urethral transition zone.
Diagnostic / clinical pearl
Clinicians should be aware that benign prostatic hyperplastic nodules can occur in the peripheral zone and may exhibit increased PSMA uptake, potentially mimicking prostate cancer.
Why it matters
This case highlights the importance of considering benign conditions in differential diagnoses when interpreting PSMA PET/CT findings in the prostate.