Improved donor-site biomechanics and functional recovery with xenogeneic acellular dermal matrix after ALT flap harvest: A prospective randomized controlled study.
J Craniomaxillofac SurgJul 30, 2026 (epub)
Tianyi Wang, Shenglin Li, Bowen Yang et al.
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In 30 seconds
This prospective randomized controlled trial evaluated the efficacy of xenogeneic acellular dermal matrix (Xeno-ADM) for fascia lata repair after anterolateral thigh (ALT) flap harvest in 200 patients. The Xeno-ADM group demonstrated significantly lower compartment pressures and inflammatory markers, along with superior functional recovery, including faster gait and lower pain scores at postoperative day 7.
Key findings
- Xeno-ADM group had significantly lower compartment pressures on postoperative days 1-5.
- Inflammatory markers (CRP) were significantly lower in the Xeno-ADM group on postoperative days 3 and 5.
- Serum muscle injury biomarkers (creatine kinase) were significantly lower in the Xeno-ADM group on postoperative days 1 and 5.
- Functional outcomes were superior in the Xeno-ADM group, with faster gait recovery and lower pain scores.
Why it matters
Effective management of donor sites is crucial in reconstructive surgery. The use of Xeno-ADM may enhance recovery and reduce complications, potentially leading to improved patient outcomes in oral cancer reconstruction.