Impact of nutritional factors on the pharmacokinetics of antipsychotics - a systematic review.
Psychiatry ResJul 13, 2026 (epub)
Clinical ResearchPsychiatry
Michael Schepp, Melanie Engel, Anna Hirschbeck et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review evaluated the impact of nutritional factors on the pharmacokinetics of antipsychotics, analyzing 48 studies. It found that food intake significantly affects drug bioavailability, with lurasidone and ziprasidone showing a 2- to 3-fold increase in AUC when taken with a meal, while amisulpride's absorption decreases by approximately 25% with food.
Key findings
- Lurasidone and ziprasidone AUC increases 2- to 3-fold when taken with a meal of at least 350-500 kcal.
- Amisulpride absorption is reduced by food intake, with a ∼25% reduction in AUC.
- Clozapine metabolism may be influenced by seasonal vitamin D variations and caffeine intake.
Why it matters
Understanding the influence of nutritional factors on antipsychotic pharmacokinetics is crucial for optimizing treatment efficacy and minimizing toxicity. Standardized guidelines for drug administration can help achieve consistent therapeutic outcomes.