Vagus nerve stimulation for refractory status epilepticus: A systematic review.
SeizureJul 25, 2026 (epub)
Clinical ResearchNeurology
Chun-Lin Kuo, Hung-Yu Lin, Chia-Kuang Tsai et al.
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In 30 seconds
This systematic review evaluated the efficacy of vagus nerve stimulation (VNS) in 61 patients with super-refractory status epilepticus (SRSE). The study found a 90% cessation rate of refractory status epilepticus after VNS implantation, with a median time to cessation of 12.7 days. However, only 38% of patients achieved long-term seizure freedom.
Key findings
- 90% of patients experienced cessation of refractory status epilepticus after VNS implantation.
- 38% of patients with follow-up of 12 months achieved seizure freedom.
- 61% of patients had unfavorable functional outcomes, with 31% mortality.
Why it matters
Refractory status epilepticus is a critical condition with high morbidity and mortality. Understanding the potential role of VNS in managing this condition can inform treatment strategies and improve patient outcomes.
What to keep in mind
The review is limited by potential publication bias and the exploratory nature of subgroup analyses.